Inflammation-based score (Glasgow prognostic score) as an independent prognostic factor in colorectal cancer patients
Annals of Surgical Treatment and Research
;
: 309-313, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-152270
ABSTRACT
PURPOSE:
This study was conducted to evaluate the systemic inflammatory response in colorectal cancer patients, and to estimate the usefulness of the Glasgow prognostic score (GPS) as a prognostic factor.METHODS:
Patients with biopsy-proven colorectal adenocarcinoma who were operated between April 2005 and December 2008 were enrolled in this study. The GPS was estimated based on the measurement of CRP and serum albumin level. The GPS was compared with other clinicopathological factors. Univariate and multivariate analyses were performed to evaluate the factors affecting cancer-specific survival.RESULTS:
GPS was significantly higher in patients with anemia, thrombocytosis, a high neutrophil to lymphocyte ratio, tumor of the colon, and large tumor. Patient age, gender, serum CEA level, tumor gross appearance, TNM stage, and tumor differentiation were not related with the GPS. In univariate analysis, hemoglobin, CEA, gross appearance of tumor, TNM stage, tumor differentiation, and GPS were associated with cancer-specific survival. In multivariate analysis, TNM stage (III or IV I or II; hazard ratio [HR], 12.322; P = 0.015), tumor differentiation (poorly differentiated well or moderately differentiated; HR, 3.112; P = 0.021), and GPS (GPS 2 GPS 0 or 1; HR, 5.168; P = 0.003) were identified as independent prognostic factors in colorectal cancer.CONCLUSION:
Our study showed that the GPS was an independent variable from tumor stage and a good and convenient prognostic factor in colorectal cancer patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Trombocitose
/
Albumina Sérica
/
Linfócitos
/
Neoplasias Colorretais
/
Adenocarcinoma
/
Análise Multivariada
/
Colo
/
Inflamação
/
Anemia
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Annals of Surgical Treatment and Research
Ano de publicação:
2014
Tipo de documento:
Artigo
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