Klotho and the Aging Process
The Korean Journal of Internal Medicine
;
: 113-122, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-152504
ABSTRACT
The klotho gene was originally identified as a putative age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. Since then, various functional aspects of the klotho gene have been investigated, leading to the identification of multiple novel endocrine axes that regulate various metabolic processes and an unexpected link between mineral metabolism and aging. The purposes of this review were to overview recent progress on Klotho research and to discuss a novel aging mechanism.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fenótipo
/
Fosfatos
/
Envelhecimento
/
Transdução de Sinais
/
Doença Crônica
/
Fósforo na Dieta
/
Fatores de Crescimento de Fibroblastos
/
Glucuronidase
/
Homeostase
/
Nefropatias
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Internal Medicine
Ano de publicação:
2011
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS