Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder
Clinical Psychopharmacology and Neuroscience
;
: 269-275, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-152979
ABSTRACT
OBJECTIVE:
Patients with bipolar disorder (BD) exhibit peripheral low-grade inflammation. The aim of the current study was to investigate the involvement of hitherto unexplored components of the tumor necrosis factor (TNF) superfamily in BD.METHODS:
Eighty patients with type I BD and 50 healthy controls matched for age and gender were enrolled in this study. All subjects were assessed with the Mini-Plus to evaluate psychiatric comorbidities; the Young Mania Rating Scale and the Hamilton Depression Rating Scale to evaluate manic and depressive symptoms severity, respectively. TNF superfamily molecules (TNF, TNF-related weak inducer of apoptosis [TWEAK], TNF-related apoptosis-inducing ligand [TRAIL], soluble TNF receptor type 1 [sTNFR1], and soluble TNF receptor type 2 [sTNFR2]) levels were measured by ELISA.RESULTS:
Patients with BD, regardless of mood state, presented increased plasma levels of sTNFR1 and TWEAK in comparison with controls.CONCLUSION:
These findings corroborate the view that TNF superfamily may play a role in BD pathophysiology.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plasma
/
Transtorno Bipolar
/
Ensaio de Imunoadsorção Enzimática
/
Comorbidade
/
Fator de Necrose Tumoral alfa
/
Apoptose
/
Receptores do Fator de Necrose Tumoral
/
Depressão
/
Ligante Indutor de Apoptose Relacionado a TNF
/
Inflamação
Limite:
Humanos
Idioma:
Inglês
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2017
Tipo de documento:
Artigo
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