The Relationship between the SNAP-25 Polymorphism and Omission Errors in Korean Children with Attention Deficit Hyperactivity Disorder
Clinical Psychopharmacology and Neuroscience
; : 222-228, 2017.
Article
em En
| WPRIM
| ID: wpr-152986
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WPRO
ABSTRACT
OBJECTIVE: This study aimed to investigate the association between the synaptosomal-associated protein 25 kDa (SNAP-25) genotype and performance on the continuous performance test (CPT) in Korean children with attention-deficit/hyperactivity disorder (ADHD). METHODS: Eighty-seven children with ADHD (mean age, 9.23±1.99 years) participated in this study. Omission errors, commission errors, reaction time, and reaction time variability on the CPT were analyzed. The single-nucleotide polymorphism (SNP) rs3746544 (1065 T>G) of SNAP-25 was genotyped to examine the association with CPT performance. RESULTS: We found significantly more omission errors on the CPT among children with the TT genotype of SNAP-25 (t=2.56, p=0.012) after correcting for multiple testing. CONCLUSION: Our results suggest the possible involvement of the SNAP-25 1065 T>G polymorphism in the inattention phenotype in children with ADHD. Further studies with more refined neuropsychological measures and much larger sample sizes are needed to confirm our findings.
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Assunto principal:
Fenótipo
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Tempo de Reação
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Transtorno do Deficit de Atenção com Hiperatividade
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Tamanho da Amostra
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Proteína 25 Associada a Sinaptossoma
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Genótipo
Limite:
Child
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Humans
Idioma:
En
Revista:
Clinical Psychopharmacology and Neuroscience
Ano de publicação:
2017
Tipo de documento:
Article