The Value of Age-adjusted Prostate Specific Antigen Density (AAPSAD) Helps to Avoid Unnecessary Biopsies in Men with Intermediate Serum PSA Levels / 대한비뇨기과학회지
Korean Journal of Urology
;
: 391-395, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-15311
ABSTRACT
PURPOSE:
Prostate biopsies were performed usually in patients with intermediate Prostate Specific Antigen (PSA) levels, however cancer detection rate was low. We would like to reduce unnecessary biopsies by developing a new PSA formula for determining cancerous conditions of the prostate. MATERIALS ANDMETHODS:
We retrospectively enrolled 99 patients with intermediate serum PSA levels. The patients were divided into two groups, the prostate cancer group (19 patients) and the benign disease group (80 patients). We developed a new formula to calculate the age-adjusted PSA density (AAPSAD), and applied it to both groups. In addition, we compared the efficacy of AAPSAD in detecting prostate cancer in men with intermediate PSA levels, compared with other PSA parameters.RESULTS:
The prostate cancer patients had higher AAPSAD than non-prostate cancer patients (p=0.000). The sensitivity, and specificity, of AAPSAD were 94.7% and 60.0%, respectively at a cut-off level of 0.6, and higher than those obtained for the Prostate Specific Antigen Density (PSAD), PSA density of the transitional zone (PSA-TZ) and free to total PSA ratio (F/T PSA ratio).CONCLUSIONS:
We suggest that the use of AAPSAD, in patients with intermediate PSA levels, may be helpful, not only to detect prostate cancer, but also to reduce unnecessary prostate biopsies.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Próstata
/
Neoplasias da Próstata
/
Biópsia
/
Estudos Retrospectivos
/
Sensibilidade e Especificidade
/
Antígeno Prostático Específico
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
Limite:
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Korean Journal of Urology
Ano de publicação:
2002
Tipo de documento:
Artigo
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