Lipid Peroxidation and Antioxidant Activity in Pregnant Women with Pregnancy-Induced Hypertension / 대한주산의학회잡지
Korean Journal of Perinatology
;
: 28-34, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-153120
ABSTRACT
OBJECTIVE:
To assess maternal circulating levels of lipid peroxides, superoxide dismutase and total antioxidants of women with pregnancy-induced hypertension.METHODS:
Cross-sectional study consisting of 18 preeclamptic, 21 uncomplicated pregnant and 22 healthy non-pregnant women. Fasting venous blood samples were collected during the 3rd trimester of antepartum period and maternal circulating levels of malondialdehyde as a lipid peroxidation product, superoxide dismutase activity and total antioxidants were measured.RESULTS:
In the preeclamptic group, lipid peroxides were significantly increased, otherwise the activity of superoxide dismutase in the erythrocytes was significantly decreased compared to normal pregnant women. The value of serum total antioxidants was similar in both groups. Strong correlation was detected between malondialdehyde and blood pressure in the pregnant women.CONCLUSION:
Preeclampsia is associated with decrease of antioxidant enzyme activity while lipid peroxidation was increased during the 3rd trimester of pregnancy. Therefore, a significant elevated lipid peroxidation and reduced superoxide dismutase activity may contribute to pathophysiology and pathogenesis of preeclampsia via vascular endothelial cell damage.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pré-Eclâmpsia
/
Superóxido Dismutase
/
Pressão Sanguínea
/
Peroxidação de Lipídeos
/
Estudos Transversais
/
Jejum
/
Gestantes
/
Células Endoteliais
/
Hipertensão Induzida pela Gravidez
/
Eritrócitos
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Coreano
Revista:
Korean Journal of Perinatology
Ano de publicação:
2002
Tipo de documento:
Artigo
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