Efficacy and tolerance of Trivastal retard 50 in combination with levodopa in the treatment Parkinson

ABSTRACT

30 patients with Parkinson’s, ages of more than 45 years treated by levodopa but clinical symptoms were unstable. Trivastal slowed the demand of increase of dose of levodopa when combining with levodopa. The adequate dose of trivastal was 1 tablet/day within 15 days, then increased to 2 tablets/day. The drug usually had an effect in 45th day, mainly on the improvement of tremble and speaking difficulty.