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Diagnostic Accuracy and Detection Rate of Real-Time PCR for Detection of Group B Streptococcal Colonization in Pregnant Women: Systemic Review of Literature and Meta-Analysis / 대한임상미생물학회지
Annals of Clinical Microbiology ; : 42-51, 2017.
Artigo em Coreano | WPRIM | ID: wpr-153458
ABSTRACT

BACKGROUND:

Group B streptococcus (Streptococcus agalactiae, GBS) was reported as a major cause of neonatal infection and death. To prevent vertical transmission, CDC recommended that all women in week 35-37 of pregnancy should receive the GBS colonization test. We conducted a systematic review and meta-analysis to evaluate diagnostic accuracy and detection rate of real-time PCR for GBS in pregnant women.

METHODS:

The literature review for GBS using real-time PCR was done including KoreaMed, Ovid-MEDLINE, Ovid-EMBASE, and Cochrane Library on November 3, 2015. 443 articles were collected. Two authors select articles and evaluated the quality of studies using Scottish Intercollegiate Guidelines Network tool independently.

RESULTS:

Diagnostic accuracy of the real-time PCR was assessed by meta-analysis through 34 articles (13,516 for real-time PCR, 1,815 for culture and other comparison test). The GBS colonization was assessed through 34 articles, which reported varying values of 2.0–69.2% using real-time PCR. The real-time PCR for GBS was shown to have overall sensitivity of 0.93 (95% CI 0.92–0.94, I2=86.3%), overall specificity of 0.96 (95% CI 0.96–0.96, I2=90.2%), SROC AUC of 0.99.

CONCLUSION:

Real-time PCR is an effective test for detecting GBS colonization in pregnant women, resulted in preventing the infection in a new born baby.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Streptococcus / Streptococcus agalactiae / Sensibilidade e Especificidade / Colo / Área Sob a Curva / Gestantes / Reação em Cadeia da Polimerase em Tempo Real Tipo de estudo: Estudo diagnóstico / Guia de Prática Clínica / Estudo prognóstico / Revisões Sistemáticas Avaliadas Limite: Feminino / Humanos / Gravidez Idioma: Coreano Revista: Annals of Clinical Microbiology Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Streptococcus / Streptococcus agalactiae / Sensibilidade e Especificidade / Colo / Área Sob a Curva / Gestantes / Reação em Cadeia da Polimerase em Tempo Real Tipo de estudo: Estudo diagnóstico / Guia de Prática Clínica / Estudo prognóstico / Revisões Sistemáticas Avaliadas Limite: Feminino / Humanos / Gravidez Idioma: Coreano Revista: Annals of Clinical Microbiology Ano de publicação: 2017 Tipo de documento: Artigo