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Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue
Archives of Plastic Surgery ; : 35-39, 2014.
Artigo em Inglês | WPRIM | ID: wpr-153627
ABSTRACT

BACKGROUND:

Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue.

METHODS:

Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens.

RESULTS:

Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining.

CONCLUSIONS:

Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pele / Dano ao DNA / Western Blotting / Citocinese / Diabetes Mellitus / Aurora Quinase A / Mitose Limite: Humanos Idioma: Inglês Revista: Archives of Plastic Surgery Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Pele / Dano ao DNA / Western Blotting / Citocinese / Diabetes Mellitus / Aurora Quinase A / Mitose Limite: Humanos Idioma: Inglês Revista: Archives of Plastic Surgery Ano de publicação: 2014 Tipo de documento: Artigo