Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue
Archives of Plastic Surgery
;
: 35-39, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-153627
ABSTRACT
BACKGROUND:
Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue.METHODS:
Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens.RESULTS:
Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining.CONCLUSIONS:
Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Dano ao DNA
/
Western Blotting
/
Citocinese
/
Diabetes Mellitus
/
Aurora Quinase A
/
Mitose
Limite:
Humanos
Idioma:
Inglês
Revista:
Archives of Plastic Surgery
Ano de publicação:
2014
Tipo de documento:
Artigo
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