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Clinicopathological Characteristics of Gastric Cancer and Survival Improvement by Surgical Treatment in the Elderly / 대한소화기학회지
The Korean Journal of Gastroenterology ; : 9-19, 2011.
Artigo em Coreano | WPRIM | ID: wpr-153664
ABSTRACT
BACKGROUND/

AIMS:

It has been known that elderly patients with gastric cancer show worse general condition and higher comorbidities. Therefore, few elderly patients undergo surgery. This study was designed to determine clinicopathological characteristics of gastric cancer in elderly patients and evaluate their survival improvements by the surgical treatment.

METHODS:

Gastric cancer patients, diagnosed at Ewha Womans University Mokdong Hospital between 2000 to 2004, were divided into two groups those aged > or =65 years vs. <65 years. Clinicopathological characteristics, incidence of postoperative complications, and survival time of patients in each group were analyzed.

RESULTS:

Total 370 patients were subjected and divided into the elderly and the younger group (55.4% vs. 44.6%). The elderly group showed higher incidences of hypertension and cardiovascular disease. Well differentiated adenocarcinoma was more frequently found in the elderly group (19.0% vs. 10.0%, p=0.025). There were no differences of operation time (242.6+/-70.7 vs. 257.3+/-83.8 min, p=0.115), postoperative hospital stays (15.8+/-10.6 vs. 14.7+/-9.8 days, p=0.361), and incidence of any complications (6.7% vs. 9.9%, p=0.309) between the two subgroups. The significant factors related with the elderly patient's survival were the tumor-node-metastasis (TNM) stage (stage I, hazard ratio [HR] 1.00; stage II, HR 1.28, 95% confidence interval [CI] 0.44-3.72; stage III, HR 4.06, 95% CI 2.08-7.92, stage IV, HR 9.78, 95% CI 4.97-19.26;p<0.001) and the treatment modality (laparoscopy, HR 1.00; open surgery, HR 3.90, 95% CI 2.43-6.26;p<0.001). The elderly patients who underwent gastric cancer surgery showed prolonged survival on TNM stage I, II, and III than those who were treated conservatively.

CONCLUSIONS:

In the elderly patients with gastric cancer, those who had received surgical treatments showed significantly higher survival rate than those who had treated conservatively. Therefore, aggressive surgical treatments should be seriously considered even for the elderly patients with gastric cancer.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Gástricas / Envelhecimento / Doenças Cardiovasculares / Adenocarcinoma / Antígeno Carcinoembrionário / Estudos Retrospectivos / Estimativa de Kaplan-Meier / Hipertensão / Tempo de Internação / Metástase Neoplásica Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Gastroenterology Ano de publicação: 2011 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Gástricas / Envelhecimento / Doenças Cardiovasculares / Adenocarcinoma / Antígeno Carcinoembrionário / Estudos Retrospectivos / Estimativa de Kaplan-Meier / Hipertensão / Tempo de Internação / Metástase Neoplásica Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Gastroenterology Ano de publicação: 2011 Tipo de documento: Artigo