Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly
Endocrinology and Metabolism
;
: 312-317, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-153725
ABSTRACT
BACKGROUND:
This study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea.METHODS:
DNA was extracted from the peripheral blood of 30 unrelated patients with acromegaly. GHR genotypes were evaluated by polymerase chain reaction and correlated with demographic data and laboratory parameters.RESULTS:
No patient had the d3/d3 genotype, while four (13.3%) had the d3/fl genotype, and 26 (86.7%) had the fl/fl genotype. Body mass index (BMI) in patients with the d3/fl genotype was significantly higher than in those with the fl/fl genotype (P=0.001). Age, gender, blood pressure, insulin-like growth factor-1, growth hormone, fasting plasma glucose, triglycerides, high density lipoprotein cholesterol, and low density lipoprotein cholesterol levels showed no significant differences between the two genotypes.CONCLUSION:
The d3-GHR polymorphism may be associated with high BMI but not with other demographic characteristics or laboratory parameters.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Triglicerídeos
/
Acromegalia
/
Glicemia
/
Pressão Sanguínea
/
Receptores da Somatotropina
/
DNA
/
Hormônio do Crescimento
/
Índice de Massa Corporal
/
Reação em Cadeia da Polimerase
/
Éxons
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Endocrinology and Metabolism
Ano de publicação:
2015
Tipo de documento:
Artigo
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