Changes in Cadmium Deposit and Histopathologic Finding of Testis, Liver and Kidney in Cadmium Exposed Rats / 대한산업의학회지
Korean Journal of Occupational and Environmental Medicine
;
: 56-68, 1994.
Artigo
em Coreano
| WPRIM
| ID: wpr-154072
ABSTRACT
To assess the changes of cadmium deposit and histopathologic finding of testis, liver and kidney, different dose of cadmium (Cd) was administered into male Sprague-Dawley rat(purchased from KIST, Korea Institute of Science and Technology) by single intravenous injection. At 12, 24, 48, 168 and 672 hours after Cd injection, tissue cadmium concentration and histopathological change were examined. Cd exposed group showed lesser weight gain than the control. Renal Cd content tended to increase in time-dependent pattern, while hepatic and testicular Cd content tended to decrease. Mean of renal Cd content to hepatic Cd content (Cd K/Cd L) also progressively increased. These results suggest that Cd might be gradually transported to kidney fro other organs. In testis and liver, degenerative changes appeared relatively in acute phase. These changes became more pronounced in testis, while less prominent in liver. In kidney, swelling of proximal tubluar cells and thickening of glomerular basement membrane appeared relatively later and these changes were progressively aggravated.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Testículo
/
Cádmio
/
Aumento de Peso
/
Ratos Sprague-Dawley
/
Membrana Basal Glomerular
/
Injeções Intravenosas
/
Rim
/
Coreia (Geográfico)
/
Fígado
Tipo de estudo:
Estudo diagnóstico
Limite:
Animais
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Occupational and Environmental Medicine
Ano de publicação:
1994
Tipo de documento:
Artigo
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