The Effect of Midazolam Premedication on Propofol Induction Using a Target Controlled Infusion (TCI) / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 1122-1128, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-154084
ABSTRACT
BACKGROUND:
Many studies indicated that the predictive accuracy of propofol TCI may be compromised by premedication with benzodiazepine which has been shown to reduce markedly the induction dose. This study was designed to examine the influence of midazolam premedication on certain parameters of treatment using the propofol TCI.METHODS:
One hundred and sixty ASA I or II patients undergoing elective surgery were randomly allocated to two groups according to premedication Group 1, glycopyrrolate 0.2 mg; Group 2, glycopyrrolate 0.2 mg and midazolam 0.07 mg/kg IM 1hr before induction. Each group divided to four subgroups (n=20 for each subgroup) according to expected target propofol concentration (4~7 microgram/ml for group 1 and 3~6 microgram/ml for group 2). Anesthesia induction within 3 min was considered as successful. Induction dose and time, success rate of induction, calculated concentration when successful induction, context sensitive decrement time when awakening concentration was 1.2 microgram/ml and side effects were checked.RESULTS:
Successful induction rate was higher in group 2 (53.3% vs 77.8% at target concentration of 5 microgram/ml, P<0.05). Mean target concentration of propofol were lower in group 2 (5.18 vs 3.87 microgram/ml, P<0.05). Induction time and dose were decreased 48.4% and 36.8% at target concentration of 4 g/ml, respectively in group 2 (P<0.05). Vital signs, average pain score and incidence of pain showed no differences between groups, but incidence of apnea was significantly increased in group 2 (P<0.05).CONCLUSION:
Group 2 showed better quality of propofol induction using a TCI in terms of induction time, induction dose and lower selected target without significant vital sign changes, but showed increased incidence of apnea compared with group 1.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Apneia
/
Pré-Medicação
/
Benzodiazepinas
/
Midazolam
/
Propofol
/
Incidência
/
Sinais Vitais
/
Glicopirrolato
/
Anestesia
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
1998
Tipo de documento:
Artigo
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