Relationship between Urine HVA and 5-HIAA Concentrations and Symptoms in Chronic Schizophrenia / 대한정신약물학회지

ABSTRACT

OBJECTS This study was purposed to investigate the relationship between urine HVA and 5-HIAA concentrations and clinical symptoms in chronic schizophrenia. METHODS: 272 patients with chronic schizophrenia, diagnosed by DSM-IV criteria, were performed to measure urine HVA and 5-HIAA concentrations and to evaluate the clinical symptoms by using BPRS, PANSS, YBOCS and HAM-D. RESULTS: Urine HVA and 5-HIAA concentrations showed significant correlation with BPRS, positive scale, negative scale and general psychopathology in PANSS and urine HVA/5-HIAA ratios found no significant correlation. Urine HVA concentrations showed significant correlattion with urine 5-HIAA concentrations and urine HVA/5-HIAA ratios had a negative correlation with urine 5-HIAA concentration. As a result of stepwise multiple regression, urine HVA concentrations were significantly correlated with BPRS and positive scale in PANSS and Urine 5-HIAA concentrations were significantly correlated with BPRS. Urine HVA/5-HIAA ratios had significant correlation with HAM-D and BPRS. CONCLUSION: These findings support the hypothesis that the role of central dopamine and serotonin system and the functional interaction of both neurotransmitters are important to clinical symptom formation of chronic schizophrenia.