Could Emesis from Epidural Anesthesia for a Cesarean Section be Controlled by Prophylactic Low-Dose Granisetron? / 대한마취과학회지
Korean Journal of Anesthesiology
;
: s13-s19, 2002.
Artigo
em Inglês
| WPRIM
| ID: wpr-154272
ABSTRACT
BACKGROUND:
Nausea and vomiting during regional anesthesia for a cesarean section are common and unpleasant complications. This study was designed to assess the efficacy of prophylactic low dose granisetron on nausea and vomiting of patients undergoing a cesarean section with epidural anesthesia in a prospective, randomized, and double blind manner.METHODS:
Sixty obstetric patients not in labor received epidural anesthesia with 20 mL of 2% lidocaine plus epinephrine (1 100,000) and 4 mL of diluted morphine 2 mg was administrated for postoperative pain control. Maternal hypotension was prevented aggressively by fluid administration and an ephedrine injection. The patients were assigned randomly to one of four groups to receive a placebo (normal saline) or granisetron in a dose of 10micro gram/kg, 20micro gram/kg, or 30micro gram/kg i.v. before peritoneal closure. Emetic episodes and emetic scores rating from 0 to 4 were observed during the 24 hours after surgery.RESULTS:
The emetic score was statistically lower in the granisetron 30micro gram/kg group than the other groups, and was lower in the granisetron 20micro gram/kg group than the placebo and granisetron 10micro gram/kg group. Adverse events were headache, dizziness, sedation and pruritus, which were not serious.CONCLUSIONS:
Prophylactic use of low dose granisetron (20-30micro gram/kg) is effective in postoperative nausea and vomiting in a cesarean section with epidural anesthesia using lidocaine and morphine when hypotension as one of the contributing factors was minimized.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Dor Pós-Operatória
/
Prurido
/
Vômito
/
Epinefrina
/
Cesárea
/
Estudos Prospectivos
/
Granisetron
/
Náusea e Vômito Pós-Operatórios
/
Tontura
/
Efedrina
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo observacional
Limite:
Feminino
/
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Korean Journal of Anesthesiology
Ano de publicação:
2002
Tipo de documento:
Artigo
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