Effects of Finasteride and Castration on Rat Ventral Prostate / 대한남성과학회지
Korean Journal of Andrology
;
: 47-53, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-154600
ABSTRACT
PURPOSE:
To compare the mechanism of cell loss and changes in the ventral prostate of young adult Sprague-Dawley rats after treatment with finasteride, a potent 5 alpha-reductase inhibitor, or castration. MATERIALS ANDMETHODS:
Rats were divided into two group finasteride treated and castrated. Finasteride-treated rats were given 1 mg/kg a day orally. The rats were sacrificed on days 1, 3, 5, 7, 10, 14, and 21. The ventral prostate was weighed and either prepared for histologic examination to detect apoptotic evidence or frozen in liquid nitrogen for the determination of the intraprostatic dihydrotestosterone (DHT) concentration and DNA content.RESULTS:
Both finasteride and castration decreased prostate weight and DNA content, the decrease being more pronounced in the castrated group. By 3 days of finasteride treatment, the intraprostatic DHT concentration decreased to a greater extent with no further significant change thereafter, whereas castration gradually decreased the intraprostatic DHT concentration up to day 10, with no further significant decrease thereafter. Apoptotic bodies were typically observed in castrated but not finasteride-treated animals.CONCLUSIONS:
Castration caused a more profound involution of rat ventral prostate than did finasteride. The extent of prostatic involution did not correlate with the intraprostatic DHT concentration. We could not find evidence of apoptosis in finasteride-treated animals.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Próstata
/
Di-Hidrotestosterona
/
DNA
/
Castração
/
Ratos Sprague-Dawley
/
Apoptose
/
Finasterida
/
Colestenona 5 alfa-Redutase
/
Nitrogênio
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Andrology
Ano de publicação:
2000
Tipo de documento:
Artigo
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