Effects of Topical Tranilast on Corneal Haze with the Pentacam(R) after Photorefractive Keratectomy

ABSTRACT

PURPOSE: To evaluate the inhibitory effect of tranilast on formation of corneal haze using the Pentacam(R) after photorefractive keratectomy (PRK). METHODS: A prospective, randomized, paired eye study was performed. A total of 60 eyes from 30 patients were enrolled in the present study. Eyes were categorized as myopic eyes or =-5 D. Patients undergoing PRK were randomized to receive tranilast in one eye and no medication in the contralateral eye. Three months postoperatively, corneal haze was measured with the Pentacam(R) and compared between the 2 groups. RESULTS: Statistical differences were not found in preoperative data in the tranilast or control groups (all P > 0.05). There was a strong decreasing density trend from the apex to the 3 mm radius in both groups (P 0.05). CONCLUSIONS: The use of tranilast after PRK did not inhibit corneal opacity. Additionally, Pentacam(R) can provide a useful objective measure of corneal haze.