Genetic Variations in TXNRD1 as Potential Predictors of Drug-Induced Liver Injury
Allergy, Asthma & Immunology Research
; : 132-136, 2012.
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em En
| WPRIM
| ID: wpr-155322
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WPRO
ABSTRACT
PURPOSE: Drug-induced liver injury (DILI) is the most common adverse drug reaction; however, it is not easily predicted. We hypothesize that DILI has a common genetic basis. Based on the findings of previous animal studies on toxic hepatitis, we selected the thioredoxin reductase 1 gene (TXNRD1) as a candidate marker of DILI for this genetic association study. METHODS: Records from 118 patients with DILI were extracted from the database of the Adverse Drug Reaction Research Group in South Korea. Causative drugs included antituberculosis drugs (n=68, 57.6%), antibiotics (n=22, 18.6%), antiepileptic drugs (n=7, 5.9%), non-steroidal anti-inflammatory drugs (n=5, 4.2%), and others (n=16, 13.7%). Seven single nucleotide polymorphisms (SNPs) in TXNRD1 (rs10735393, rs4964287, rs4595619, rs10861201, rs11111997, rs4246270, and rs4246271) were scored in 118 DILI patients and in 120 drug-matched controls without liver injury. RESULTS: No differences were found between the frequencies of any of the 7 SNPs in the cases and controls; however, a significant association was found between a TTA haplotype composed of rs10735393, rs4964287, and rs4595619 and DILI using an allele model (odds ratio, 1.79; 95% confidence interval, 1.18-2.73; P=0.008; Bonferroni corrected P=0.024). CONCLUSIONS: These results suggest that genetic variations in TXNRD1 favor the development of DILI, although a larger confirmative study is needed.
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Assunto principal:
Polimorfismo Genético
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Variação Genética
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Haplótipos
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Polimorfismo de Nucleotídeo Único
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Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
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Alelos
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Tiorredoxina Redutase 1
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Doença Hepática Induzida por Substâncias e Drogas
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Estudos de Associação Genética
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República da Coreia
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
País/Região como assunto:
Asia
Idioma:
En
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2012
Tipo de documento:
Article