The Effects of Repeated Stress on the GABAergic Neurotransmission in Rats / 신경정신의학
Journal of Korean Neuropsychiatric Association
;
: 190-198, 2000.
Artigo
em Coreano
| WPRIM
| ID: wpr-155900
ABSTRACT
OBJECTIVES:
Changes of GABAergic neurotransmission in response to the application of different types of environmental stress have been the subject of research for over two decades. However, the nature of the changes induced by stress appear to show a dependent phenomena on the type and duration of stressor agent employed.METHODS:
For this reason, this study was performed to observe the effects of repeated stress on the radioligands binding to GABA A/benzodiazepine receptors of discrete brain regions. The author also examined the activity of GABA transaminase and the concentration of endogenous GABA. Male Sprague-Dawley rats, weighing 150-200g were forced to suffer an immobilization stress for 2 hours during 14 consecutive days.RESULTS:
Repeated immobilization stress decreased the binding of [3H]flunitrazepam on the benzodiazepine receptor in the cortex, hippocampus and hypothalamus. Saturation experiments followed by scatchard analyses of the results showed decreased density of benzodiazepine receptor and the affinity remained unchanged. Repeated immobilization stress did not affect the binding of [3H]muscimol on the GABAA receptor, the activity of GABA transaminase, and the concentration of endogenous GABA in the brain regions.CONCLUSIONS:
From these results, it can be concluded that repeated immobilization stress modulated GABAergic neurotransmission via downregulation of the benzodiazepine receptor in the brain.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Regulação para Baixo
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Ratos Sprague-Dawley
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Receptores de GABA
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Receptores de GABA-A
/
Transmissão Sináptica
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Ácido gama-Aminobutírico
/
4-Aminobutirato Transaminase
/
Hipocampo
/
Hipotálamo
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
Journal of Korean Neuropsychiatric Association
Ano de publicação:
2000
Tipo de documento:
Artigo
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