Chemotherapy and patient co-morbidity in ventral site hernia development / 부인종양
Journal of Gynecologic Oncology
;
: 246-250, 2009.
Artigo
em Inglês
| WPRIM
| ID: wpr-15593
ABSTRACT
OBJECTIVE:
The risk factors associated with early ventral site hernia development following cancer surgery are ill defined and associated with an undetermined incidence.METHODS:
We analyzed 1,391 gynecologic cancer patient charts to identify the number of post-operative ventral site hernias over a nearly 6 year period. The following study variables were noted for evaluation patient demographics, disease co-morbidity (hypertension, cardiovascular disease, diabetes), body mass index (BMI), treatment (e.g., chemotherapy regimen), intra-operative (e.g., bleeding) and postoperative (e.g., infection) complications, time to hernia development and length of hospital stay.RESULTS:
Twenty-six gynecologic cancer patients who developed a post-operative ventral hernia and subsequently underwent herniorrhaphy by our gynecologic oncology service were identified. The patient group's overall time to initial hernia development was 11.23 months. Following a multiple regression analysis, we found that treatment (e.g., bevacizumab, liposomal doxorubicin or radiotherapy associated with compromised wound healing [p=0.0186] and disease co-morbidity [0.0432]) were significant prognostic indicators for an accelerated time to hernia development. Moreover, five patients underwent treatment associated with compromised wound healing and also had disease co-morbidity. In this sub-group, post-operative hernia development occurred more rapidly (3.8 months) than the overall group of patients. BMI and age did not impact time to hernia development (p>0.05).CONCLUSION:
In the present gynecologic cancer patient series, a tendency for early post-operative hernia development appeared to coincide with treatment associated with compromised wound healing and disease co-morbidity. Gynecologic cancer surgeons should anticipate this potential complication and consider employing prophylactic intra-operative mesh to potentially prevent this condition.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Cicatrização
/
Doenças Cardiovasculares
/
Doxorrubicina
/
Índice de Massa Corporal
/
Demografia
/
Incidência
/
Fatores de Risco
/
Anticorpos Monoclonais Humanizados
/
Herniorrafia
/
Bevacizumab
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
Idioma:
Inglês
Revista:
Journal of Gynecologic Oncology
Ano de publicação:
2009
Tipo de documento:
Artigo
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