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Clinical significance of serum alanine aminotransferase and lifestyle intervention in children with nonalcoholic fatty liver disease / 소아과
Korean Journal of Pediatrics ; : 362-367, 2016.
Artigo em Inglês | WPRIM | ID: wpr-155950
ABSTRACT

PURPOSE:

This study aimed to investigate the clinical significance of serum alanine aminotransferase (ALT) levels in children with nonalcoholic fatty liver disease (NAFLD) and the effect of lifestyle intervention on NAFLD.

METHODS:

The clinical data of 86 children diagnosed with NAFLD were reviewed retrospectively. Forty-six patients belonged to the elevated ALT group and 40 to the normal ALT group. The clinical parameters of patients with NAFLD were also compared based on the status of ALT levels after lifestyle intervention.

RESULTS:

Patients with elevated ALT had significantly higher body mass index (BMI) scores than those with normal ALT (P<0.05). Of all the patients with elevated ALT, 89% exhibited moderate or severe degree of fatty change in the liver on ultrasonographic examination, whereas most patients with normal ALT exhibited mild or moderate degree changes. Liver biopsy was performed in 15 children with elevated ALT and all showed mild histological changes. Of all patients with elevated ALT, 49% achieved normal ALT levels after lifestyle intervention. Those with more severe histological changes tended to have continuously increasing ALT levels. There was no correlation between the normalization of posttreatment ALT level and BMI, as well as ultrasonographic findings at diagnosis.

CONCLUSION:

ALT elevation in NAFLD is highly associated with higher BMI scores and more severe degree of fatty changes on ultrasonographic examination. Lifestyle intervention can significantly improve ALT in children with NAFLD. The degree of histologic changes appears to be a predictor of the treatment response to NAFLD.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Biópsia / Índice de Massa Corporal / Estudos Retrospectivos / Diagnóstico / Alanina / Alanina Transaminase / Hepatopatia Gordurosa não Alcoólica / Estilo de Vida / Fígado Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Criança / Humanos Idioma: Inglês Revista: Korean Journal of Pediatrics Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Biópsia / Índice de Massa Corporal / Estudos Retrospectivos / Diagnóstico / Alanina / Alanina Transaminase / Hepatopatia Gordurosa não Alcoólica / Estilo de Vida / Fígado Tipo de estudo: Estudo diagnóstico / Estudo observacional / Estudo prognóstico Limite: Criança / Humanos Idioma: Inglês Revista: Korean Journal of Pediatrics Ano de publicação: 2016 Tipo de documento: Artigo