Implication of ADAM-8, -9, -10, -12, -15, -17, and ADAMTS-1 in Implantational Remodeling of a Mouse Uterus
Yonsei Medical Journal
; : 558-567, 2006.
Article
em En
| WPRIM
| ID: wpr-156132
Biblioteca responsável:
WPRO
ABSTRACT
In the present study, whether the ADAM-8, -9, -10, -12, -15, -17, and ADAMTS-1 proteins might play a role in mouse uterus during periimplantation period was investigated. Immunoblotting analyses demonstrated that all ADAM proteins consistently appeared throughout days 1 to 8 of pregnancy but with a variation depending on the species of ADAM gene, the progression of pregnancy, and the site of the uterus. Immunohistochemical analyses indicated that ADAM proteins were localized in the luminal or glandular epithelial layers with a varying intensity depending on the species of ADAM and the progression of pregnancy. Particularly ADAM-8, -12, and -15, were predominantly located in the implantation site of the uterine tissues, whereas little or no protein was localized in the interimplantation site. Based upon these observations, it is suggested that the ADAMs might play an important role in the remodeling of the mouse uterus during the periimplantation period.
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Texto completo:
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Índice:
WPRIM
Assunto principal:
Implantação do Embrião
/
Fatores de Tempo
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Útero
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Imuno-Histoquímica
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Immunoblotting
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Regulação da Expressão Gênica
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Ciclo Estral
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Desenvolvimento Embrionário
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Proteínas ADAM
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Camundongos Endogâmicos ICR
Limite:
Animals
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Pregnancy
Idioma:
En
Revista:
Yonsei Medical Journal
Ano de publicação:
2006
Tipo de documento:
Article