Infectivity of Orientia tsutsugamushi to Various Eukaryotic Cells and Their Cellular Invasion Mechanism
Journal of the Korean Society for Microbiology
;
: 435-443, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-15622
ABSTRACT
Orientia tsutsugamushi is obligate intracellular bacterium that grows within the cytoplasm of the eukaryotic host cells. Therefore capability of the attachment, entry into the host cell and intracellular survival should be critical process for oriential infection. In this study we investigated the cellular invasion mechanism of Orientia tsutsugamushi and the role of transmembrane heparan sulfate proteoglycan, which binds diverse components at the cellular microenvironment and is implicated as host cell receptors for a variety of microbial pathogens. First of all Orientia tsutsugamushi can invade a wide range of nonprofessional phagocytic cells including fibroblast, epithelial cells a#nd endothelial cells of various host species, including B and T lymphocytes. Thus, it was postulated that the attachment of O. tsutsugamushi requires the recognition of ubiquitous surface structures of many kinds of host cells. Treatments with heparan sulfate and heparin inhibited the infection of Orientia tsutsugamushi in dose-dependent manner for L cell, mouse fibroblast, whereas other glycosaminoglycans such as chondroitin sulfate had no effect. Collectively, these findings provide strong evidence that initial interaction with heparan sulfate proteoglycan is required for the oriential invasion into host cells.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fagócitos
/
Orientia tsutsugamushi
/
Heparina
/
Linfócitos T
/
Sulfatos de Condroitina
/
Proteoglicanas de Heparan Sulfato
/
Citoplasma
/
Células Endoteliais
/
Células Epiteliais
/
Células Eucarióticas
Limite:
Animais
Idioma:
Coreano
Revista:
Journal of the Korean Society for Microbiology
Ano de publicação:
1999
Tipo de documento:
Artigo
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