Subacute Sclerosing Panencephalitis: Clinical Experience of 6 Cases / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 281-289, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-156262
ABSTRACT
PURPOSE:
Subacute sclerosing panencephalitis(SSPE) is a severe and usually fatal neurodegenerative disorder of childhood and adolescence. The etiology is related to previous measles infection especially during the first 2 years of life. Since recent measles epidemics in Korea may increase the late risk of SSPE, the authors investigated the clinical characteristics of SSPE focusing on brain MRI.METHODS:
Six cases(4 males, 2 females) of SSPE patients were retrospectively reviewed for clinical, EEG, laboratory and brain MRI findings.RESULTS:
Four of 6 had a history of measles infection in the first year of life. Clinical manifestations were as followsmyoclonus(6), falling(4), ataxia(4), dysarthria(3), seizures (2), involuntary movements(2), tremor(2), head drop(1), sleep disturbance(1). In all cases, CSF IgG, CSF IgG/albumin ratio, and CSF/serum IgG index increased, oligoclonal bands were positive, and CSF antimeasles antibodies were positive. Frontal high amplitude sigma activities and anteriorly-accentuated multifocal epileptiform discharges were noted on EEG. Brain MRI revealed T2-weighted high signal intensity of the deep white matter.CONCLUSION:
The diagnosis of SSPE depends on characteristic clinical features and elevation of measles antibodies in CSF, supported by others including EEG, CSF and brain MRI findings. We hope the clinical characteristics we mentioned may be useful for the early diagnosis and active management of SSPE in Korea.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Convulsões
/
Panencefalite Esclerosante Subaguda
/
Encéfalo
/
Imunoglobulina G
/
Imageamento por Ressonância Magnética
/
Estudos Retrospectivos
/
Doenças Neurodegenerativas
/
Bandas Oligoclonais
/
Diagnóstico Precoce
/
Diagnóstico
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo de rastreamento
Limite:
Adolescente
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of the Korean Child Neurology Society
Ano de publicação:
2002
Tipo de documento:
Artigo
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