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Single Nucleotide Polymorphisms of Cytokine Genes are Associated with Fibrosis of the Intrahepatic Bile Duct Wall in Human Clonorchiasis
The Korean Journal of Parasitology ; : 145-151, 2009.
Artigo em Inglês | WPRIM | ID: wpr-156341
ABSTRACT
This study examined the association of cytokine gene polymorphisms with intrahepatic bile duct wall fibrosis in human clonorchiasis. A total of 240 residents in Heilongjiang, China underwent ultrasonography, blood sampling, and stool examination. Single nucleotide polymorphism (SNP) sites for IFN-gamma (+874 T/A), IL-10 (-1,082 G/A, -819 C/T, -592 C/A), TNF-alpha (-308 G/A), and TGF-beta1 (codon 10 T/C, codon 25 G/C) genes were observed with the TaqMan allelic discrimination assay. No significant correlation was observed between individual cytokine gene polymorphisms and intrahepatic duct dilatation (IHDD). Among individuals with clonorchiasis of moderate intensity, the incidence of IHDD was high in those with IFN-gamma intermediate-producing genotype, +874AT (80.0%, P = 0.177), and in those with TNF-alpha low-producing genotype, -308GG (63.0%, P = 0.148). According to the combination of IFN-gamma and TNF-alpha genotypes, the risks for IHDD could be stratified into high (intermediate-producing IFN-gamma and low producing TNF-alpha), moderate, and low (low-producing IFN-gamma and high producing TNF-alpha) risk groups. The incidence of IHDD was significantly different among these groups (P = 0.022) 88.9% (odds ratio, OR = 24.0) in high, 56.5% (OR = 3.9) in moderate, and 25.0% (OR = 1) in low risk groups. SNP of IFN-gamma and TNF-alpha genes may contribute to the modulation of fibrosis in the intrahepatic bile duct wall in clonorchiasis patients.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ductos Biliares Intra-Hepáticos / Fibrose / China / Citocinas / Clonorquíase / Polimorfismo de Nucleotídeo Único / Frequência do Gene Limite: Adolescente / Adulto / Idoso / Aged80 / Criança / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2009 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Ductos Biliares Intra-Hepáticos / Fibrose / China / Citocinas / Clonorquíase / Polimorfismo de Nucleotídeo Único / Frequência do Gene Limite: Adolescente / Adulto / Idoso / Aged80 / Criança / Feminino / Humanos / Masculino País/Região como assunto: Ásia Idioma: Inglês Revista: The Korean Journal of Parasitology Ano de publicação: 2009 Tipo de documento: Artigo