Expression of the Brother of the Regulator of Imprinted Sites Gene in the Sputum of Patients with Lung Cancer
The Korean Journal of Thoracic and Cardiovascular Surgery
; : 378-383, 2014.
Article
em En
| WPRIM
| ID: wpr-156571
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Brother of the regulator of imprinted sites (BORIS) is a putative new oncogene that is classified as a cancer germline gene; however, its role in the development of cancer is unclear. This study investigated the expression of BORIS in lung cancer and its clinical implications. METHODS: The expression of BORIS messenger ribonucleic acid (mRNA) in the sputum of 100 patients with lung cancer (50 with squamous cell carcinoma, 36 with adenocarcinoma, and 14 with small-cell carcinoma) was evaluated by reverse transcription polymerase chain reaction. RESULTS: The overall expression rate of BORIS in patients with lung cancer was 36.0%: 19 of 50 squamous cell carcinomas (38.0%), 13 of 36 adenocarcinomas (36.1%), and 4 of 14 (28.6%) small-cell carcinomas. There was no significant difference in the BORIS expression according to age, gender, or histologic type. However, the mRNA expression of BORIS was significantly related to the pathologic cancer stage (p=0.004) and lymph node metastasis (p=0.001). The expression of the melanoma antigen gene family A1-6 was not associated with the expression of BORIS. CONCLUSION: Our results suggest that the expression of BORIS might be a negative prognostic factor in lung cancers and implicate BORIS as a molecular target for immunotherapy.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Oncogenes
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Escarro
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RNA
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RNA Mensageiro
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Carcinoma de Células Escamosas
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Adenocarcinoma
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Reação em Cadeia da Polimerase
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Irmãos
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Transcrição Reversa
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Imunoterapia
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
The Korean Journal of Thoracic and Cardiovascular Surgery
Ano de publicação:
2014
Tipo de documento:
Article