Application of Iron Related Magnetic Resonance Imaging in the Neurological Disorders / 대한임상신경생리학회지
Korean Journal of Clinical Neurophysiology
;
: 1-7, 2014.
Artigo
em Coreano
| WPRIM
| ID: wpr-156824
ABSTRACT
Iron is an important element for brain oxygen transport, myelination, DNA synthesis and neurotransmission. However, excessive iron can generate reactive oxygen species and contribute neurotoxicity. Although brain iron deposition is the natural process with normal aging, excessive iron accumulation is also observed in various neurological disorders such as neurodegeneration with brain iron accumulation, Parkinson's disease, Alzheimer's disease, multiple sclerosis, Friedreich ataxia, and others. Magnetic resonance image (MRI) is a useful method for detecting iron deposits in the brain. It can be a powerful tool for diagnosis and monitoring, while furthering our understanding of the role of iron in the pathophysiology of a disease. In this review, we will introduce the mechanism of iron toxicity and the basics of several iron-related MRI techniques. Also, we will summarize the previous results concerning the clinical application of such MR imagings in various neurological disorders.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxigênio
/
Doença de Parkinson
/
Encéfalo
/
Envelhecimento
/
DNA
/
Ataxia de Friedreich
/
Imageamento por Ressonância Magnética
/
Espécies Reativas de Oxigênio
/
Transmissão Sináptica
/
Doenças Neurodegenerativas
Tipo de estudo:
Estudo diagnóstico
Idioma:
Coreano
Revista:
Korean Journal of Clinical Neurophysiology
Ano de publicação:
2014
Tipo de documento:
Artigo
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