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Randomized Comparison of the Platelet Inhibitory Efficacy between Low Dose Prasugrel and Standard Dose Clopidogrel in Patients Who Underwent Percutaneous Coronary Intervention
Korean Circulation Journal ; : 82-88, 2014.
Artigo em Inglês | WPRIM | ID: wpr-15687
ABSTRACT
BACKGROUND AND

OBJECTIVES:

Increased bleeding rates with standard dose prasugrel have led to increased questions about the effectiveness and safety of the lower maintenance dose. We compared platelet inhibitory efficacy between low dose prasugrel and standard dose clopidogrel in patients on maintenance dose dual antiplatelet therapy. SUBJECTS AND

METHODS:

Forty-three patients who underwent percutaneous coronary intervention were randomized to receive 75 mg clopidogrel (n=23) or 5 mg prasugrel (n=20). Another 20 patients were allocated to 10 mg prasugrel as a reference comparison group. All patients (weight, > or =60 kg; age, 235) was significant lower in the 5 mg prasugrel group than that in the 75 mg clopidogrel group (15.0% vs. 56.5%, p=0.010).

CONCLUSION:

Prasugrel (5 mg) is more potent antiplatelet therapy than 75 mg clopidogrel in non-low body weight and non-elderly patients on a maintenance dose dual antiplatelet therapy.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Testes de Função Plaquetária / Peso Corporal / Distribuição Aleatória / Aspirina / Antagonistas do Receptor Purinérgico P2Y / Intervenção Coronária Percutânea / Cloridrato de Prasugrel / Hemorragia Tipo de estudo: Ensaio Clínico Controlado Limite: Humanos Idioma: Inglês Revista: Korean Circulation Journal Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Testes de Função Plaquetária / Peso Corporal / Distribuição Aleatória / Aspirina / Antagonistas do Receptor Purinérgico P2Y / Intervenção Coronária Percutânea / Cloridrato de Prasugrel / Hemorragia Tipo de estudo: Ensaio Clínico Controlado Limite: Humanos Idioma: Inglês Revista: Korean Circulation Journal Ano de publicação: 2014 Tipo de documento: Artigo