Prevalence and Clinical Significance of p15 Methylation in Acute Leukemia / 대한진단검사의학회지
The Korean Journal of Laboratory Medicine
;
: 139-143, 2005.
Artigo
em Coreano
| WPRIM
| ID: wpr-156946
ABSTRACT
BACKGROUND:
CpG islands' methylation of p15 promoter region is associated with inactivation of the p15 gene, which negatively regulates the cell cycle. We investigated the prevalence and prog-nostic significance of p15 gene methylation in AML and ALL patients, and sequentially analyzed p15 methylation during the follow-up.METHODS:
This study included 52 and 25 bone marrow aspirates from 33 AML and 22 ALL patients, respectively; p15 methylation was analyzed by methylation specific PCR.RESULTS:
The methylation of the p15 gene was observed in 57% of newly diagnosed AML, 70% of relapsed AML, and 23% of newly diagnosed ALL patients. Moreover, p15 methylation was found in 65% of AML and 33% of ALL patients with a normal karyotype. No association was found between p15 methylation status and prognostic factors or clinical outcomes; however, p15 methylation status correlated well with the clinical and pathologic features of disease status during the follow-up.CONCLUSIONS:
The methylation of the p15 gene may be of use as a marker for disease monitoring of acute myelogeneous leukemia, especially in patients with a normal karyotype, although p15 methy-lation doesn't seem to be associated with prognosis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Medula Óssea
/
Leucemia
/
Ciclo Celular
/
Reação em Cadeia da Polimerase
/
Prevalência
/
Seguimentos
/
Regiões Promotoras Genéticas
/
Cariótipo
/
Metilação
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Coreano
Revista:
The Korean Journal of Laboratory Medicine
Ano de publicação:
2005
Tipo de documento:
Artigo
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