The medical-term results of the operation of perforated gastroduodenal ulceration combining with the radical treatment of H. pylori

ABSTRACT

Of 115 patients with perforated peptic ulcer, 96,5% (111/115) were treated by simple surgical closure followed by Helicobacter pylori (H.pylori) eradication. 111 H.pylori positive patients received triple therapy including Omeprazole 20 mg b.d + Clarithromycine 500mg b.d + Amoxicillin 1,000 mg b.d for 7 days (OCA-7). Follow -up endoscopiy was performed over 2 month and over 1 year after hospital discharge for surveillance of ulcer healing and determination of H.pylori status. Of 107 patients who did underwent follow-up endoscopy, 95.3% (102/107) had H.pylori eradicated and initial ulcer healing rate was 92.5% (99/107). After over 1 year, H. pylori reinfection rate was 16.8% (16/95) and ulcer ralapse rate was 7.4% (7/95). The simple surgical closure followed by H.pylori eradication prevents ulcer recurrence in patients with H.pylori associated perforated peptic ulcers.