Inhibition of Fas-mediated Apoptosis of Rheumatoid Synovial Cells by TGF-beta and IL-1 beta / 대한류마티스학회지
The Journal of the Korean Rheumatism Association
;
: 110-116, 1999.
Artigo
em Coreano
| WPRIM
| ID: wpr-157311
ABSTRACT
OBJECTIVE:
To investigate the proliferative and anti-apoptotic effects of TGF-beta and IL-1beta on rheumatoid synovial cells.METHODS:
Synovial cells obtained from surgical procedure of the rheumatoid joint were cultured with TFG-beta and IL-1beta The proliferative response of synovial cells was examined by non-radioactive cell proliferation assay. Fas-demiated apoptosis of synovial cells was measured by flow cytometry after addition of anti-Fas antibody.RESULTS:
TGF-beta and IL-1betaproliferated synovial cells in a dose-dependent manner. They also made synovial cells resistant to anti-Fas antibody induced apoptosis.CONCLUSION:
TGF-beta and IL-1betapromotes synovial cell proliferation possibly through interference with Fas-mediated apoptosis, suggesting their role in synovial hyperplasis in rheumatoid arthritis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Artrite Reumatoide
/
Fator de Crescimento Transformador beta
/
Interleucina-1
/
Apoptose
/
Proliferação de Células
/
Interleucina-1beta
/
Citometria de Fluxo
/
Articulações
Idioma:
Coreano
Revista:
The Journal of the Korean Rheumatism Association
Ano de publicação:
1999
Tipo de documento:
Artigo
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