Cancer Stem Cells in Primary Liver Cancers: Pathological Concepts and Imaging Findings
Korean Journal of Radiology
;
: 50-68, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-157428
ABSTRACT
There is accumulating evidence that cancer stem cells (CSCs) play an integral role in the initiation of hepatocarcinogenesis and the maintaining of tumor growth. Liver CSCs derived from hepatic stem/progenitor cells have the potential to differentiate into either hepatocytes or cholangiocytes. Primary liver cancers originating from CSCs constitute a heterogeneous histopathologic spectrum, including hepatocellular carcinoma, combined hepatocellular-cholangiocarcinoma, and intrahepatic cholangiocarcinoma with various radiologic manifestations. In this article, we reviewed the recent concepts of CSCs in the development of primary liver cancers, focusing on their pathological and radiological findings. Awareness of the pathological concepts and imaging findings of primary liver cancers with features of CSCs is critical for accurate diagnosis, prediction of outcome, and appropriate treatment options for patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Células-Tronco Neoplásicas
/
Neoplasias dos Ductos Biliares
/
Ductos Biliares Intra-Hepáticos
/
Imageamento por Ressonância Magnética
/
Tomografia Computadorizada por Raios X
/
Colangiocarcinoma
/
Carcinoma Hepatocelular
/
Neoplasias Hepáticas
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Radiology
Ano de publicação:
2015
Tipo de documento:
Artigo
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