Vortex Keratopathy in a Patient Receiving Vandetanib for Non-Small Cell Lung Cancer
Korean Journal of Ophthalmology
;
: 355-357, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-15768
ABSTRACT
We report a case of vortex keratopathy in a patient treated with vandetanib for non-small cell lung cancer (NSCLC). A 44-year-old female who underwent two cycles of chemotherapy for NSCLC complained of visual blurring in both eyes after the initiation of vandetanib, an anti-epidermal growth factor receptor (EGFR) and anti-vascular endothelial growth factor receptor 2 protein tyrosine kinase inhibitor. On ophthalmic examination, visual acuities were 20 / 20 OU and, with the exception of diffuse vortex keratopathy in both eyes, other findings were unremarkable. Vandetanib is believed to have caused vortex keratopathy in this patient. Anti-EGFR properties affecting normal corneal epithelial cell migration and wound healing or drug associated metabolite deposition, which is the case in numerous drug-associated vortex keratopathies, may be possible underlying mechanisms in the formation of this corneal complication.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piperidinas
/
Quinazolinas
/
Acuidade Visual
/
Seguimentos
/
Carcinoma Pulmonar de Células não Pequenas
/
Córnea
/
Doenças da Córnea
/
Microscopia Acústica
/
Diagnóstico Diferencial
/
Relação Dose-Resposta a Droga
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Ophthalmology
Ano de publicação:
2011
Tipo de documento:
Artigo
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