Frontotemporal Lobar Degeneration
Journal of Korean Geriatric Psychiatry
;
: 55-61, 2007.
Artigo
em Coreano
| WPRIM
| ID: wpr-157802
ABSTRACT
Frontotemporal lobar degeneration (FTLD) is a progressive dementia with prominent neuropsychiatric features, aphasia or both. FTLD predominantly affects the frontal and anterior part of temporal cortex. FTLD is classified into frontotemporal dementia (FTD), progressive nonfluent aphasia (PA), and semantic dementia (SD). FTLD is estimated to account for 20% of cases of degenerative dementia with presenile onset. This disease typically has onset in the mid- or early fifties. FTD is characterized by behavioral change and executive dysfunction, PA features a progressive nonfluent aphasia. SD is characterized by a progressive semantic aphasia and associative agnosia. Structural imaging shows atrophy of the frontal lobe and the anterior portion of the temporal lobe, bilaterally symmetric or asymmetric. Pathologically, FTLD can be classified into tau-positive pathology, tau-negative, ubiquitin positive pathology, dementia lacking distinctive histology. At present, there are no specific pharmacological therapies approved for use in any of the FTLD syndrome.
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Assunto principal:
Afasia
/
Patologia
/
Atrofia
/
Lobo Temporal
/
Ubiquitina
/
Demência
/
Agnosia
/
Afasia Primária Progressiva não Fluente
/
Degeneração Lobar Frontotemporal
/
Demência Frontotemporal
Idioma:
Coreano
Revista:
Journal of Korean Geriatric Psychiatry
Ano de publicação:
2007
Tipo de documento:
Artigo
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