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Parenteral Nutrition-Associated Cholestasis in Very Low Birth Weight Infants: A Single Center Experience / 대한소아소화기영양학회지
Pediatric Gastroenterology, Hepatology & Nutrition ; : 61-70, 2016.
Artigo em Inglês | WPRIM | ID: wpr-158490
ABSTRACT

PURPOSE:

Parenteral nutrition (PN)-associated cholestasis (PNAC) is one of the most common complications in very low birth weight infants (VLBWIs). The aim of this study is to evaluate the risk factors of PNAC in VBLWIs.

METHODS:

We retrospectively reviewed the medical records of 322 VLBWIs admitted to the neonatal intensive care unit of our hospital from July 1, 2009 to December 31, 2013. We excluded 72 dead infants; 6 infants were transferred to another hospital, and 57 infants were transferred to our hospital at 2 weeks after birth. The infants were divided into the cholestasis and the non-cholestasis groups. PNAC was defined as a direct bilirubin level of ≥2.0 mg/dL in infants administered with PN for ≥2 weeks.

RESULTS:

A total of 187 VLBWI were enrolled in this study; of these, 46 infants developed PNAC. Multivariate logistic regression analysis showed that the risk factors of PNAC in VLBWI were longer duration of antimicrobial use (odds ratio [OR] 4.49, 95% confidence interval [95% CI] 4.42-4.58), longer duration of PN (OR 2.68, 95% CI 2.41-3.00), long-term lack of enteral nutrition (OR 2.89, 95% CI 2.43-3.37), occurrence of necrotizing enterocolitis (OR 2.40, 95% CI 2.16-2.83), and gastrointestinal operation (OR 2.19, 95% CI 2.03-2.58).

CONCLUSION:

The results of this study suggest that shorter PN, aggressive enteral nutrition, and appropriate antimicrobial use are important strategies in preventing PNAC.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Bilirrubina / Terapia Intensiva Neonatal / Modelos Logísticos / Prontuários Médicos / Colestase / Estudos Retrospectivos / Fatores de Risco / Nutrição Enteral / Nutrição Parenteral / Recém-Nascido de muito Baixo Peso Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos / Lactente / Recém-Nascido Idioma: Inglês Revista: Pediatric Gastroenterology, Hepatology & Nutrition Ano de publicação: 2016 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Bilirrubina / Terapia Intensiva Neonatal / Modelos Logísticos / Prontuários Médicos / Colestase / Estudos Retrospectivos / Fatores de Risco / Nutrição Enteral / Nutrição Parenteral / Recém-Nascido de muito Baixo Peso Tipo de estudo: Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Humanos / Lactente / Recém-Nascido Idioma: Inglês Revista: Pediatric Gastroenterology, Hepatology & Nutrition Ano de publicação: 2016 Tipo de documento: Artigo