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Mean Platelet Volume and Vitamin D Level
Annals of Laboratory Medicine ; : 98-103, 2014.
Artigo em Inglês | WPRIM | ID: wpr-158565
ABSTRACT

BACKGROUND:

Vitamin D deficiency and a high mean platelet volume (MPV) are related to cardiovascular disease. We investigated whether vitamin D deficiency is associated with high MPV.

METHODS:

This study included 434 patients without chronic disease who were not taking vitamin D or calcium supplements. Vitamin D was measured by chemiluminescent microparticle immunoassay on the Architect-I2000 system (Abbott Diagnostics, USA), and MPV was measured on the Cell-Dyn Ruby analyzer (Abbott Diagnostics). Patients were divided into Groups 1 (138 [men/women, 46/92]), 2 (148 [men/women, 54/94]), and 3 (148 [men/women, 50/98]) according to vitamin D levels of 20 ng/mL, respectively.

RESULTS:

The vitamin D level in Group 1 (7.7+/-1.9 ng/mL) was lower than that in Group 2 (15.1+/-1.6 ng/mL, P<0.001) and Group 3 (25.6+/-6.3 ng/mL, P<0.001). The MPV in Group 3 (7.5+/-1.0 fL) was lower than that in Group 1 (8.1+/-1.1 fL, P<0.001) and Group 2 (7.9+/-1.0 fL, P=0.009). Linear regression analysis showed that low levels of vitamin D (beta=-0.109, P=0.019) was independently associated with increased MPV.

CONCLUSIONS:

There was a strong association between a low vitamin D level and a high MPV; therefore, vitamin D deficiency may be associated with increased MPV.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina D / Deficiência de Vitamina D / Glicemia / Plaquetas / Imunoensaio / Fatores Etários / Tamanho Celular / Medições Luminescentes Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Inglês Revista: Annals of Laboratory Medicine Ano de publicação: 2014 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Vitamina D / Deficiência de Vitamina D / Glicemia / Plaquetas / Imunoensaio / Fatores Etários / Tamanho Celular / Medições Luminescentes Limite: Adolescente / Adulto / Idoso / Aged80 / Feminino / Humanos / Masculino Idioma: Inglês Revista: Annals of Laboratory Medicine Ano de publicação: 2014 Tipo de documento: Artigo