Mosaic Turner syndrome associated with schizophrenia
Annals of Pediatric Endocrinology & Metabolism
;
: 42-44, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-158570
ABSTRACT
Turner syndrome is a sex-chromosome disorder; occurring in 1 in 2,500 female births. There are sporadic few case reports of concomitant Turner syndrome with schizophrenia worldwide. Most Turner females had a 45,X monosomy, whereas the majority of comorbidity between Turner syndrome and schizophrenia had a mosaic karyotype (45,X/46,XX). We present a case of a 21-year-old woman with Turner syndrome, mosaic karyotype (45,X/46,XX), showing mental retardation, hypothyroidism, and schizophrenia. HOPA gene within Xq13 is related to mental retardation, hypothyroidism, and schizophrenia. Our case may be a potential clue which supports the hypothesis for involvement of genes on X chromosome in development of schizophrenia. Further studies including comorbid cases reports are need in order to discern the cause of schizophrenia in patients having Turner syndrome.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esquizofrenia
/
Síndrome de Turner
/
Cromossomo X
/
Comorbidade
/
Parto
/
Cariótipo
/
Hipotireoidismo
/
Deficiência Intelectual
/
Monossomia
/
Mosaicismo
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Annals of Pediatric Endocrinology & Metabolism
Ano de publicação:
2014
Tipo de documento:
Artigo
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