Comparison of Lidocaine , Bupivacaine and Lidocaine - Bupivacaine Mixture for Epidural Blockade for Cesarean Section / 대한마취과학회지

ABSTRACT

In a double-blind clinical study, single-dose lumbar epidural blockade was instituted in 45 healthy patients undergoing cesarean section. Patients were randomly assigned to one of three groups. Each group received treatment with a different local anesthetic solution used were 2.0% Lidocaine HCL 20 ml in group I, 0.5% Bupivacaine HCL 20 ml in group II and Lidocaine-Bupivacaine Mixture in the ratio of 11 20 ml in group III The injections were made at the third lumbar interspace. The local anesthetic was injected directly through 176 Tuohy needle at 1 ml/s with the bevel directed cephalad(11 ml) and caudad(9 ml), The onset times were fastest in group I and slowest in group III. The durations were shortest in group L The times reguired to reach the highest level in group I and III were shorter than group II. The Apgar scores and blood pressure changes were similar in the diifferent groups. The frequency of pain sense was highest in group II. It is concluded that Lidocaine and Lidocaine-Bupivacine Mixture are superior to Bupivacaine for lumbar epidural blockade for cesarean section.