Usefulness of drug provocation tests in children with a history of adverse drug reaction / 소아과
Korean Journal of Pediatrics
;
: 304-309, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-158741
ABSTRACT
PURPOSE:
There are very few reports of adverse drug reactions (ADR) and almost no study of drug provocation test (DPT) in Korean children. We aimed to assess the role of DPT in children with unpredictable ADRs, and compare the causative drugs and clinical characteristics between detailed history of ADRs and result of DPTs.METHODS:
We included 16 children who were experienced ADRs referred to pediatric allergy clinic at Ajou University Hospital (January 2006 to December 2009). With various suspected drugs, 71 DPTs were done in 16 patients using our own protocol, and skin tests to antibiotics were combined in ADRs to antibiotics in medical history.RESULTS:
There were 17 (23.9%) positive DPTs results out of 71 individual DPTs, and 11 patients (68.8%) from 16 patients were positive to at least one drug. Drugs causing positive reactions were acetaminophen in 5 (31%), Non-steroidal anti-inflammatory drugs in 4 (25%), penicillin in 3 (19%), cephalosporin in 2 (13%), and cotrimoxazole, macrolide and lactose in 1 each.CONCLUSION:
DPT seems a safe and useful procedure to confirm causative drug and identify safely administering alternative drugs in children with ADR.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Penicilinas
/
Tionas
/
Testes Cutâneos
/
Combinação Trimetoprima e Sulfametoxazol
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Hipersensibilidade
/
Lactose
/
Acetaminofen
/
Antibacterianos
Tipo de estudo:
Guia de Prática Clínica
/
Estudo prognóstico
Limite:
Criança
/
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Pediatrics
Ano de publicação:
2011
Tipo de documento:
Artigo
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