Size-reductive Neoadjuvant Immunotherapy using Imiquimod in Squamous Cell Carcinoma of the Lower Lip
Annals of Dermatology
;
: 75-80, 2007.
Artigo
em Inglês
| WPRIM
| ID: wpr-158867
ABSTRACT
rcinoma (SCC) is the second most common skin cancer. In particular, invasive SCC has a high risk of metastasis and sometimes, this can be fatal. At present, the treatment of choice for invasive SCC is complete excision with a proper surgical margin, but most cases of SCC develop on cosmetically-sensitive areas, so sometimes significant scarring or deformities can lead to an unhappy result. An 80 year-old female presented with a 4x1.5cm sized SCC on her lower lip. Although surgery was the first line therapy for this invasive SCC, a cosmetically poor outcome was expected. Thus the patient did not want to undergo a surgical operation, so we had to explore other treatment options. Recently there have been many reports that show imiquimod 5% cream is effective in the treatment of invasive SCC. Therefore we started topical therapy with imiquimod 5% cream five times a week. After 6 months, the lesion size was reduced to 2x1.5cm and we could remove the remnant tumor by wedge resection with cosmetically acceptable result. We suggest this neo-adjuvant immunotherapy can be an alternative for the treatment of cosmetically-critical SCC and present this case as a good example that has shown successful size-reductive neoadjuvant immunotherapy using imiquimod in invasive SCC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Neoplasias Cutâneas
/
Anormalidades Congênitas
/
Carcinoma de Células Escamosas
/
Cicatriz
/
Terapia Neoadjuvante
/
Imunoterapia
/
Lábio
/
Metástase Neoplásica
Limite:
Idoso
/
Aged80
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Annals of Dermatology
Ano de publicação:
2007
Tipo de documento:
Artigo
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