Topical Aminolaevulinic Acid-Photodynamic Therapy for the Treatment of Mild to Moderate Inflammatory Acne

ABSTRACT

BACKGROUND: Photodynamic therapy (PDT) using aminolevulinic acid (ALA) is a new technique. PDT is being studied extensively and is used in a variety of dermatology settings. OBJECTIVE: The purpose of this study was to evaluate the safety and efficacy of topical ALA-PDT in patients with mild to moderate inflammatory acne. METHOD: Ten patients were enrolled in a clinical trial to evaluate ALA-PDT with activation by intense pulsed light. They were given a 20% topical ALA photosensitizing agent that remained in contact with the skin for 60 minutes before irradiation. No additional treatment was provided after PDT. RESULTS: The Korean acne grading system was used for clinical assessment. Our results showed a statistically significant clinical improvement of the inflammatory acne at eight weeks after two sessions of treatment. Side effects such as slight discomfort, burning and stinging were reported during the irradiation. CONCLUSION: ALA-PDT is a safe and effective treatment modality for inflammatory acne.