Epileptic Spasms, a Journey to Find Therapeutics Based on Pathophysiology / 대한소아신경학회지
Journal of the Korean Child Neurology Society
;
(4): 113-120, 2017.
Artigo
em Coreano
| WPRIM
| ID: wpr-159144
ABSTRACT
After the first description of infantile spasms (IS) in 1841, extensive clinical and laboratory investigations have been done to find the pathophysiology and the optimal treatments. The concept of the “infantile spasms” has been evolved to the “epileptic spasms”, which includes the spasms outside the infancy the pathophysiology of IS, however, is still unknown. There have been a few randomized trials that proved the efficacy of the anecdotally used drugs in IS including hormonal therapy and vigabatrin. Due to its relative low incidence (1/2000) and the variable etiologies, clinical studies have difficulties in making a clear conclusion. Thus, animal models were eagerly sought to find the pathophysiology based treatments with definite efficacy and several models are now available. In this paper, the current understandings of the epileptic spasms as well as the translational researches using the animal models of IS are reviewed. The latest evidences of therapeutics in IS are discussed shortly.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Espasmo
/
Espasmos Infantis
/
Incidência
/
Vigabatrina
/
Modelos Animais
/
Pesquisa Translacional Biomédica
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo de incidência
/
Estudo prognóstico
Limite:
Lactente
/
Recém-Nascido
Idioma:
Coreano
Revista:
Journal of the Korean Child Neurology Society
Ano de publicação:
2017
Tipo de documento:
Artigo
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