bcl-2 and p53 Gene Expression in Colonic Adenoma and Carcinoma / 대한암학회지
Journal of the Korean Cancer Association
;
: 89-99, 1998.
Artigo
em Coreano
| WPRIM
| ID: wpr-15938
ABSTRACT
PURPOSE:
Recently, it is suggested that the inhibitian of apoptosis is associated with tumorigenesis of colon. Bcl-2 gene is an important inhibitory regulator of apoptosis, and bcl-2 acts antagonistly with the wild type p53 gene, one of the tumor suppressor genes, in apoptosis. To detnmine the role of bcl-2 and p53 gene in colonic tumorigenesis, we performed the study. MATERIALS ANDMETHODS:
We tested the tissue obtained by polypectomy and surgical resection by immunohistochemical staining for Bcl-2 and p53.RESULTS:
We found that in normal colonic tissue, the Bcl-2 was sparcely expressed, and the p53 was expressed sporadically. The rate of positivity of staining was below 5%. However, in colonic adenoma and colon cancer tissue, Bcl-2 and p53 were expressed more than in nonnal colonic tissue(p<0.05). (Scoring in Colonic adenoma Bcl-2 6.2+/-1.1, p53 5.7+/-1.0; Scoring in Colonic carcinoma Bcl-2 4.7+/-1.0, p53 8.3+/-0.9)CONCLUSION:
Our results suggested that the bcl-2 and p53 play an important role in colonic tumorigenesis.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Adenoma
/
Genes p53
/
Genes Supressores de Tumor
/
Apoptose
/
Colo
/
Neoplasias do Colo
/
Genes bcl-2
/
Carcinogênese
Idioma:
Coreano
Revista:
Journal of the Korean Cancer Association
Ano de publicação:
1998
Tipo de documento:
Artigo
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