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The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children
Journal of the Korean Pediatric Society ; : 1591-1598, 2000.
Artigo em Coreano | WPRIM | ID: wpr-159509
ABSTRACT

PURPOSE:

Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children.

METHODS:

We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification was based on the serum C-peptide levels, presence of ketoacidosis, autoantibodies, and insulin dependence.

RESULTS:

Among 177 diabetic children, 147(83.1%) were classified as type 1 and 21(11.9%) as type 2, and 12(57.1%) children in type 2 were obese. All patients with age of onset before 9 were type 1. In cases of type 1, initial serum C-peptide levels were 1.0ng/mL (6%). All patients with initial serum C-peptide level above 1.5ng/mL were type 2. Four patients initially diagnosed as type 2 DM changed to type 1 during follow-up, and 2 patients of type 1 DM changed to type 2. Only 55.4% of type 1 DM patients had insulin autoantibody, islet cell cytoplasmic antibody or anti-glutamic acid decarboxylase antibodies.

CONCLUSION:

Most diabetic children in Korea were classified as type 1. Our results suggest that insulin requiring lean patients with positive autoantibody should be classified as type 1 even if their serum C-peptide levels are within normal range, and the clinical types could be changed during follow-up in a small proportion of diabetic children.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Valores de Referência / Autoanticorpos / Peptídeo C / Seguimentos / Ilhotas Pancreáticas / Classificação / Idade de Início / Citoplasma / Diabetes Mellitus / Insulina Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Criança / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of the Korean Pediatric Society Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Valores de Referência / Autoanticorpos / Peptídeo C / Seguimentos / Ilhotas Pancreáticas / Classificação / Idade de Início / Citoplasma / Diabetes Mellitus / Insulina Tipo de estudo: Estudo observacional / Estudo prognóstico Limite: Criança / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of the Korean Pediatric Society Ano de publicação: 2000 Tipo de documento: Artigo