Immunohistochemical study on the expression of calcium binding proteins (calbindin-D28k, calretinin, and parvalbumin) in the cerebral cortex and in the hippocampal region of nNOS knock-out(-/-) mice / 대한해부학회지
Anatomy & Cell Biology
;
: 106-115, 2011.
Artigo
em Inglês
| WPRIM
| ID: wpr-159930
ABSTRACT
Nitric oxide (NO) modulates the activities of various channels and receptors to participate in the regulation of neuronal intracellular Ca2+ levels. Ca2+ binding protein (CaBP) expression may also be altered by NO. Accordingly, we examined expression changes in calbindin-D28k, calretinin, and parvalbumin in the cerebral cortex and hippocampal region of neuronal NO synthase knockout(-/-) (nNOS-/-) mice using immunohistochemistry. For the first time, we demonstrate that the expression of CaBPs is specifically altered in the cerebral cortex and hippocampal region of nNOS-/- mice and that their expression changed according to neuronal type. As changes in CaBP expression can influence temporal and spatial intracellular Ca2+ levels, it appears that NO may be involved in various functions, such as modulating neuronal Ca2+ homeostasis, regulating synaptic transmission, and neuroprotection, by influencing the expression of CaBPs. Therefore, these results suggest another mechanism by which NO participates in the regulation of neuronal Ca2+ homeostasis. However, the exact mechanisms of this regulation and its functional significance require further investigation.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteína G de Ligação ao Cálcio S100
/
Proteínas de Ligação ao Cálcio
/
Imuno-Histoquímica
/
Proteínas de Transporte
/
Córtex Cerebral
/
Cálcio
/
Transmissão Sináptica
/
Óxido Nítrico Sintase
/
Homeostase
/
Neurônios
Limite:
Animais
Idioma:
Inglês
Revista:
Anatomy & Cell Biology
Ano de publicação:
2011
Tipo de documento:
Artigo
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