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Humoral and Cell Mediated Immune Response After Immunization with Varicella Vaccine (Oka/LG)
Journal of the Korean Pediatric Society ; : 170-178, 1998.
Artigo em Coreano | WPRIM | ID: wpr-16008
ABSTRACT

PURPOSE:

We evaluated the humoral and cellular immune response to varicella-zoster virus after vaccination with varicella vaccine (Oka/LG strain).

METHODS:

The seroprevalence rate of fluorescent antibody to membrane antigen (FAMA) was evaluated among 178 children and 15 adults. After vaccination, seroconversion rate of FAMA, varicella-zoster virus (VZV) specific IgG and cell mediated immune response to glycoprotein I was performed.

RESULTS:

The seropositive rate of FAMA against VZV in healthy children ages 3 to 6 was 43.1%. A past history of chickenpox illness was confirmed in 15.2% of children who had positive response in FAMA assay in 90.9%. 34.5% of those without a past history of chickenpox had antibodis. The seropositive rate in children vaccinated with varicella vaccine in the past was found to be 46.3% in questionnaire and 44.4% in immunization schedule, lower than that of other studies (greater than 90%). The seroconversion rates in children vaccinated with the Oka/LG were 97.1% with 2,500pfu and 100.0% with 5,000pfu. Antibodies appearing after the Oka/LG vaccination were found to have glycoprotein I zone confirmed by western blotting. The rate of cell mediated immune response was 88.2% in children and 100.0% in adults.

CONCLUSION:

Further investigation about the effect of the various varicella vaccines used in Korea and about the cause of their immunzation failure after vaccination is needed.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Imunoglobulina G / Vacinas / Glicoproteínas / Estudos Soroepidemiológicos / Varicela / Western Blotting / Inquéritos e Questionários / Esquemas de Imunização / Imunização / Vacinação Limite: Adulto / Criança / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of the Korean Pediatric Society Ano de publicação: 1998 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Imunoglobulina G / Vacinas / Glicoproteínas / Estudos Soroepidemiológicos / Varicela / Western Blotting / Inquéritos e Questionários / Esquemas de Imunização / Imunização / Vacinação Limite: Adulto / Criança / Humanos País/Região como assunto: Ásia Idioma: Coreano Revista: Journal of the Korean Pediatric Society Ano de publicação: 1998 Tipo de documento: Artigo