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Comparison of therapeutic results between combination therapy of peginterferon alpha-2a plus ribavirin and interferon alpha-2b plus ribavirin according to treatment duration in patients with chronic hepatitis C / 대한간학회지
The Korean Journal of Hepatology ; : 46-57, 2008.
Artigo em Coreano | WPRIM | ID: wpr-160190
ABSTRACT
BACKGROUND/

AIMS:

This study compared the efficacy and safety of combined peginterferon alfa (PEG-IFN) and ribavirin with that of combined interferon alpha (IFN-alpha) and ribavirin, according to the treatment duration in Korean patients with chronic hepatitis C.

METHODS:

Medical records of 86 patients treated with PEG-IFN and ribavirin (mean age, 50.7 years; males/females, 57/29; genotypes 1/2, 59/27) and 134 patients treated with IFN-alpha and ribavirin (mean age, 50.9 years; males/females 74/60; genotypes 1/2, 79/55) were reviewed. Ribavirin was administered at doses of 600-1,200 mg and 600-800 mg in patients with genotypes 1 and 2, respectively.

RESULTS:

Sustained virological responses (SVRs) were evident in 68.4% and 41.7% of genotype 1 patients treated for 48 weeks in the PEG-IFN and IFN-alpha groups, respectively (P=0.021), and in 94.1% and 64.9% of genotype 2 patients treated for 24 weeks (P=0.026). Some genotype 1 patients treated for 24 weeks in the PEG-IFN group, who all exhibited negative HCV PCR results at week 12, showed an SVR of 87.5% (7/8).

CONCLUSIONS:

The rate of SVRs in Korean patients with chronic hepatitis C was higher for combined PEG-IFN and ribavirin than for combined IFN-alpha and ribavirin. Further study is needed to clarify the outcome of short-term therapy in patients with a rapid or early virological response.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Antivirais / Polietilenoglicóis / Ribavirina / RNA Viral / Estudos Retrospectivos / Resultado do Tratamento / Interferon-alfa / Hepacivirus / Hepatite C Crônica / Quimioterapia Combinada Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Hepatology Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Antivirais / Polietilenoglicóis / Ribavirina / RNA Viral / Estudos Retrospectivos / Resultado do Tratamento / Interferon-alfa / Hepacivirus / Hepatite C Crônica / Quimioterapia Combinada Tipo de estudo: Estudo observacional Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Coreano Revista: The Korean Journal of Hepatology Ano de publicação: 2008 Tipo de documento: Artigo