Clinical outcome of pegylated interferon and ribavirin therapy for chronic hepatitis C / 대한간학회지
The Korean Journal of Hepatology
;
: 36-45, 2008.
Artigo
em Coreano
| WPRIM
| ID: wpr-160191
ABSTRACT
BACKGROUND/AIMS:
The purpose of this study is to elucidate the efficacy and safety of combined peginterferon and ribavirin therapy in Korean patients with chronic HCV infection.METHODS:
We retrospectively analyzed the clinical records of 84 patients. Thirty five patients with genotype 1 HCV infection were treated with peginterferon alpha-2a 180 microgram/week and ribavirin 1,000-1,200 mg/day for 48 weeks, and 49 patients with genotype non-1 were treated with peginterferon alpha-2a 180 microgram/week and ribavirin 800 mg/day for 24 weeks.RESULTS:
An early virologic response was seen in 87.0% of patients with genotype 1 HCV. An end of treatment response (ETR) was seen in 82.6% and 97.6% of patients with genotype 1 and genotype non-1, respectively. An overall sustained virologic response (SVR) was seen in 53 patients (82.8%) of the 64 patients in 16 (69.6%) of 23 patients with genotype 1 and in 37 (90.2%) of 41 patients with genotype non-1. An end of treatment biochemical response was seen in 58 patients (90.6%) [genotype 1, 20 patients (87.0%); genotype non-1, 38 patients (92.7%)], and a sustained biochemical response was achieved in 49 patients (76.6%) [genotype 1, 14 patients (60.9%); genotype non-1, 35 patients (85.4%)]. Independent factors affecting an SVR were HCV genotype and the baseline HCV RNA level.CONCLUSIONS:
This study shows that a combination therapy of peginterferon and ribavirin is highly effective for chronic HCV infection, producing a high SVR and ETR.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Antivirais
/
Polietilenoglicóis
/
Ribavirina
/
Resultado do Tratamento
/
Hepatite C Crônica
/
Reação em Cadeia da Polimerase Via Transcriptase Reversa
/
Quimioterapia Combinada
/
Interferon alfa-2
/
Genótipo
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Coreano
Revista:
The Korean Journal of Hepatology
Ano de publicação:
2008
Tipo de documento:
Artigo
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