Initial Hematochezia and Kidney Involvement are Important Prognostic Factors of Adult Onset Henoch-Schonlein Purpura in Korea
Journal of Rheumatic Diseases
;
: 254-261, 2012.
Artigo
em Coreano
| WPRIM
| ID: wpr-160533
ABSTRACT
OBJECTIVE:
Henoch-Schonlein purpura (HSP) is a systemic vasculitis, characterized by small-vessel leukocytoclastic vasculitis with the deposition of immune complexes containing IgA. It is the most common acute vasculitic disorder affecting children but is relatively uncommon in adults. We investigated the clinical features and factors affecting the prognosis of adult HSP in Korea.METHODS:
From 1996 to 2011 seventy patients over 15 years of age with HSP were retrospectively analyzed.RESULTS:
Thirty eight patients (54.3%) were female and the age at disease onset ranged from 15 to 75 years (35.0+/-15.8 years). Purpuric skin rash was observed in all patients and arthralgia was present in 34 patients (48.6%). GI symptoms and kidney involvements were observed in 28 patients (40.0%) and 34 patients (48.6%), respectively. Complete remission was achieved in 46 patients (65.7%). The remission group showed a lower incidence of hematochezia (p=0.044), hematuria (p=0.008), and proteinuria (p=0.011) at diagnosis than the no remission group. About 10% of adult HSP patient progressed to chronic kidney disease (CKD), which showed higher a incidence of nephrotic range proteinuria. Only nephrotic range proteinuria at diagnosis was a significant risk factor for CKD (OR=16.7, p=0.008, 95% CI=2.1~133.1).CONCLUSION:
Hematochezia, hematuria and proteinuria at the diagnosis of HSP are important prognostic factors in predicting remission. In addition, HSP patients with nephrotic range proteinuria at diagnosis have an increased risk of renal failure.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Proteinúria
/
Vasculite por IgA
/
Vasculite
/
Imunoglobulina A
/
Incidência
/
Estudos Retrospectivos
/
Fatores de Risco
/
Vasculite Leucocitoclástica Cutânea
/
Artralgia
Tipo de estudo:
Estudo de etiologia
/
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Criança
/
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of Rheumatic Diseases
Ano de publicação:
2012
Tipo de documento:
Artigo
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