Interleukin-32 Gamma as a New Face in Inflammatory Bone Diseases
Journal of Rheumatic Diseases
;
: 14-20, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-160555
ABSTRACT
Interleukin-32 (IL-32), a recently identified pro-inflammatory cytokine, is involved in the pathogenesis and progression of infections, cancer, chronic inflammation, and autoimmune disease. IL-32γ is the most active isoform in cell death and cell activation among nine distinct isoforms of IL-32. IL-32γ potentiates both osteogenic and osteoclastogenic capacities, and is critical in the coupling of bone resorption and bone formation for maintenance of bone homeostasis. IL-32γ is strongly associated with inflammatory bone disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoporosis. In this review, we summarize current research on the role of IL-32γ in inflammatory bone disorders, highlighting this cytokine as a novel target for prognostic marker and control of these diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteogênese
/
Osteoporose
/
Artrite Reumatoide
/
Doenças Autoimunes
/
Espondilite Anquilosante
/
Doenças Ósseas
/
Reabsorção Óssea
/
Morte Celular
/
Isoformas de Proteínas
/
Homeostase
Idioma:
Inglês
Revista:
Journal of Rheumatic Diseases
Ano de publicação:
2017
Tipo de documento:
Artigo
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